SC35MH-E
SC35MH KT RRRR GLF
SC35MH-E KT  -  - - V GLF
N
C
Cleavage
Site
Fusion
Peptide
v carries a valine instead of a polybasic cleavage site.
Elastase
No Protease
Trypsin
No Protease
SC35MH-E
SC35MH
v is strictly elastase-dependent.
Hours
Viral titer [Log10(pfu/ml)]
SC35MH without protease
SC35MH-E with elastase
MDCK
Vero
v and grows to similar high titers on MDCK and Vero cells like the wild-type.
Challenge