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OVERVIEW AND CURRENT SITUATION OF AVIAN INFLUENZA ( H5NI ) IN INDONESIA
  • SARDIKIN GIRIPUTRO


  • PRESENTED AT
  • 3RD BIRD FLU SUMMIT
  • GENEVE 14-15 NOVEMBER 2006
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Global Cumulative Number of Human Avian Influenza (WHO)
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Over 17.000 Islands, 33 Provinces,  Major Islands : Sumatra, Kalimantan, Celebes, Java, Papua . Total Population 224.000.000
Java Population : 120.000.000
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CHRONOLOGY OF HPAI OUTBREAK IN INDONESIA
  • 25 JAN 2004     :   HPAI OUTBREAK IN POULTRY


  • 5 MARCH 2005 :   H5N1 IN PIGS IN TANGERANG


  • 9 JULY 2005     :   FIRST HUMAN CASE,
  •                                   FAMILY  CLUSTER
  •                                  (3 CASES,  ALL  DIED)


  • 16 SEPT 2005   : SECOND FAMILY CLUSTER
  •                                  (2 CONFIRMED CASES, 1 DIED)


  • 19 SEPT 2005   : DECLARATION OF HPAI
  •                                  OUTBREAK IN HUMAN
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Animal Outbreaks and Human Cases of Avian Influenza in Indonesia as of November 2006
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Distribution of AI Cases by month of onset
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Distribution of Cases by Age Group and Sex
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Distribution of AI Cases by Type of Exposure
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Distribution of AI Cases by Area
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Distribution Of AI cases by Occupation
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Distribution of AI Cases by Type of Exposure in Children
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Clusters in Indonesia :  Do clusters indicate     (to some extent) human to human transmission ?
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BIGGEST FAMILY CLUSTER IN NORTH SUMATRA
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Viral genetic (nucleotide) changes in patients of the Karo cluster
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Government policy. WHAT’S ON (1)

  • Develop  12.000  “alert village” in 2006 to early detect AI cases and strengthening integrated surveillance through Participatory Disease Surveillance(PDS) and Participatory Disease Response(PDR)


  • Avian Flu campaign and exercise (orientation, drill and table-top)


  • Oseltamivir stockpile and distribution (12 million caps as of the end 2006)


  • Seeking interpandemic H5N1 vaccine (in collaboration with Baxter) and  H5N1 rapid antigen test for humans (in Collaboration with Temasek Life Science Lab. etc)


  • Clinical Research under South East Asia Influenza Clinical Trial Network in collaboration with Thailand, Vietnam, US National Institute of Health, Oxford University, Welcome trust, US CDC etc


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Government policy. WHAT’S ON (2)
  • All Avian Influenza cases should be taken care and hospitalized at designated AI referral hospitals free of charge


  • Currently there are 44 designated referral hospital, the number of referral hospital will be expanded until 100. And 3 existing confirmatory laboratories (NIfHRD, Namru-2, Eijkmann Institute for Bio molecular) in Jakarta, and will be expanded into  10  regional center in other provinces


  • Satellite hospitals may conduct an initial assessment before referring to referral hospitals as long as isolation room is available and universal precaution is applicable


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Lesson learnt
  • Over 700 cases have been investigated: most of them were excluded by lab-based examination
  • As of November 3,  2006 = 72 confirmed cases/55 fatality (CFR=76,4%)
  • Time between onset and notification = 5 days
  • Time between notification and lab results: available within 3 days for 70% of cases
  • Urban/semi urban > rural
  • Over 72% confirmed cases were in Java island
  • Majority of cases were in advanced stage
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Lesson learnt

  • Indonesia is currently in WHO pandemic alert phase 3
    • Primarily animal infection
    • Some human infections
  • Clusters due to self-limited human-to-human transmission does NOT change phase 3 to 4
  • No identified changes in functional characteristic so far



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Amantadine Resistance
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AI outbreak in poultry (diagrammatic)    & human cases, Thailand 2003 – 2004
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The First Indonesian Index Case
showing Bilateral Pneumonia
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ACKNOWLEDGEMENT :
  • GINA SAMAAN & WHO TEAM,
  • JAKARTA OFFICE
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Thank you very much !
(we are not new mutants…)